In the Turkish city of Antakya near the Syrian border, where 10-storey buildings crumbled onto the streets, Reuters journalists saw rescue work being conducted on one out of dozens of mounds of rubble.
The temperature was close to freezing on Tuesday as the rain came down and there was no electricity or fuel in the city.
The magnitude 7.8 quake hit Turkey and neighbouring Syria early on Monday, toppling thousands of buildings including many apartment blocks, wrecking hospitals, and leaving thousands of people injured or homeless.
In Turkey, the death toll climbed to 2921 people, Turkey's Disaster and Emergency Management Authority (AFAD) said.
The death toll in Syria, already devastated by more than 11 years of war, stands at more than 1500, according to the Syrian government and a rescue service in the insurgent-held northwest.
Freezing winter weather hampered search efforts through the night.Â
In Kahramanmaras, north of Antakya, families gathered around fires and wrapped themselves in blankets to stay warm.
AFAD said nearly 8000 people have been rescued from 4,758 buildings destroyed in the tremors a day earlier.
It said 13,740 search and rescue personnel were deployed and more than 41,000 tents, 100,000 beds and 300,000 blankets had been sent to the region. "The delivery of personnel and vehicles continued uninterrupted during the night," it said.
The earthquake, which was followed by aftershocks, was the biggest recorded worldwide by the US Geological Survey since one in the remote South Atlantic in August 2021.
Another earthquake of 5.6 magnitude struck central Turkey on Tuesday, the European Mediterranean Seismological Centre said.
Monday's quake was the deadliest in Turkey since one of similar magnitude in 1999 that killed more than 17,000. Nearly 16,000 were reported injured in Monday's quake.
Poor internet connections and damaged roads between some of the worst-hit Turkish cities, homes to millions of people, hindered efforts to assess the impact and plan help.
Turkish President Tayyip Erdogan, preparing for a tough election in May, called the quake a historic disaster and said authorities were doing all they could.
In the Turkish city of Iskenderun, rescuers climbed an enormous pile of debris that was once part of a state hospital's intensive care unit in search of survivors. Health workers did what they could to tend to the new rush of injured.
"We have a patient who was taken into surgery but we don't know what happened," said Tulin, a woman in her 30s, standing outside the hospital, wiping away tears and praying.
In Syria, the effects of the quake were compounded by the destruction of more than 11 years of civil war.
In the rebel-held northwest, the death toll stands at more than 740 people, according to the Syrian civil defence, a rescue service known for digging people from the rubble of government air strikes.
The civil defence said hundreds of families were trapped under the rubble and time was running out to save them.
A top United Nations humanitarian official in Syria said fuel shortages and the harsh weather were creating obstacles to its response.
"The infrastructure is damaged, the roads that we used to use for humanitarian work are damaged, we have to be creative in how to get to the people ... but we are working hard," UN resident coordinator El-Mostafa Benlamlih told Reuters in an interview via video link from Damascus.
The Syrian health ministry said the death toll in government-held areas stood at 764 people.
