Her death was confirmed on Thursday by the Claims Conference, a New York-based Conference on Jewish Material Claims Against Germany.
CNN reported on Thursday that she died at a nursing home in Bellmore, New York.
"Rose was an example of fortitude but now we are obligated to carry on in her memory," Greg Schneider, Claims Conference executive vice-president, said in a statement.
"The lessons of the Holocaust must not die with those who endured the suffering."
Girone was born in 1912, in Janow, Poland. Her family moved to Hamburg, Germany, when she was six.
She married Julius Mannheim in 1937 through an arranged marriage.
When her husband was arrested and sent to the Buchenwald Nazi concentration camp, Girone was eight months pregnant.
After her husband's release, the family fled Breslau, Germany, to Japan-occupied Shanghai, where in 1941 Jewish refugees were rounded up into a ghetto.
When the war was over, they began receiving mail from Girone's relatives in the US, and with their help, they boarded a ship to San Francisco in 1947.
They arrived in New York City in 1947. She later started a knitting store with the help of her mother.
"She was a strong lady, resilient. She made the best of terrible situations," her daughter, Holocaust survivor Reha Bennicasa, said in a statement.
"She was very level-headed, very commonsensical. There was nothing I couldn't bring to her to help me solve - ever - from childhood on."
Girone later divorced Mannheim. In 1968, she met Jack Girone, the same day her granddaughter was born.
By the next year they were married. He died in 1990.
About 245,000 Holocaust survivors are still alive and about 14,000 of those live in New York, according to the Claims Conference.
Their numbers are quickly dwindling, as most are very old and often of frail health, with a median age of 86.
Six million European Jews and people from other minorities were killed by the Nazis and their collaborators during the Holocaust.
When asked in 1996 for the message she would like to leave for her daughter and granddaughter, she said: "Nothing is so very bad that something good shouldn't come out of it. No matter what it is."
with AP
28°C