Netanyahu's White House visit on Thursday, his first since before president Donald Trump left office in 2020, comes at a time of growing pressure on all three to find an endgame to the nine-month war that has left more than 39,000 dead in Gaza.
Dozens of Israeli hostages and the remains of others who have died are also still languishing in Hamas captivity.
Biden is pressing to get Israel and Hamas to seal his proposal to release remaining hostages in Gaza over three phases - something that would be a legacy-affirming achievement for the 81-year-old Democrat, who abandoned his re-election bid and endorsed Harris.
It could also be a boon for Harris in her bid to succeed him.
President Joe Biden and Vice-President Kamala Harris will meet Israel's PM at an important moment. (AP PHOTO)
White House officials say the negotiations are in the closing stages but there are issues that need to be resolved.
Following their midday talks, Biden and Netanyahu will meet the families of American hostages.
Harris, who will meet separately with Netanyahu later, is trying to demonstrate she has the mettle to serve as commander in chief.
She is also being scrutinised by those on the political left who say Biden has not done enough to force Netanyahu to end the war and by Republicans looking to brand her as insufficient in her support for Israel.
A senior administration official, who briefed reporters on the condition of anonymity under ground rules set by the White House, said there was "no daylight between the president and vice-president" on Israel.
Netanyahu, meanwhile, is trying to navigate his own delicate political moment.
He faces pressure from the families of hostages demanding a ceasefire agreement to bring their loved ones home and from far-right members of his governing coalition who demand he resist any deal that could keep Israeli forces from eliminating Hamas.
Pro-Palestine supporters railed against Benjamin Netanyahu during his visit to Washington. (AP PHOTO)
Netanyahu, in a fiery address before a joint session of Congress on Wednesday, offered a robust defence of Israel's conduct during the war and lashed out against accusations by the International Criminal Court of Israeli war crimes.
He made the case that Israel, in its fight against Iran-backed Hamas, was effectively keeping "Americans boots off the ground while protecting our shared interests in the Middle East".
The Israeli leader spent scant time discussing the ongoing negotiations.
"Remember this: our enemies are your enemies," Netanyahu told lawmakers.
"Our fight, it's your fight. And our victory will be your victory."
Netanyahu used his speech to praise Biden for his administration's support in the aftermath of the October 7 attack on Israel.
But he also went out of his way to note action that Trump took that benefited Israel, including recognising Israel's sovereignty over the Golan Heights, confronting Iran's aggression and moving the US embassy from Tel Aviv to Jerusalem.
