"There is no reason, rationale or justification to support this decision that will affect our people and nations ... Nobody wins with this decision," Sheinbaum said at her regular morning press conference.
Trump's tariff actions went live just after midnight in Washington DC after an initial 30-day pause, during which Mexican officials engaged in talks with the US and bolstered security at the US-Mexico border.
Trump on Monday declared that Mexico, along with Canada and China, had failed to do enough to stem the flow of the deadly fentanyl opioid and its precursor chemicals into the US.
Sheinbaum said Mexico had collaborated with the US on migration, security and anti-drug trafficking.
"In these 30 days, decisive actions were taken against organised crime and fentanyl trafficking, as well as bilateral meetings on security and trade," Sheinbaum said.
Sheinbaum said she would give details on Mexico's response, including retaliatory tariffs, at an event in the capital's iconic Zocalo square on Sunday.
The delay may indicate indicating Mexican officials still hope to de-escalate the trade war set off by Trump.
The Mexican peso weakened on Tuesday morning, trading down about one per cent against the US dollar.
with AP
