Otis on Wednesday slammed into Acapulco in the state of Guerrero as one of the strongest hurricanes to ever hit Mexico's Pacific coast, flooding streets, ripping roofs off homes and hotels, and severing communications, road and air access.
The toll remains unclear, with downed phone service and electricity lines making it hard for officials to assess the extent of the damage, but no immediate reports of fatalities as of Wednesday evening.
About 8400 members of Mexico's army, air force and national guard were deployed in and near Acapulco to assist in clean-up efforts, the defence ministry said.
Classes were cancelled for students across the state for a second day, and Governor Evelyn Salgado said on social media authorities were working to restore electricity and reactivate drinking water pumps in Acapulco.
Mudslides from Hurricane Otis have closed the main highway connecting Acapulco with Mexico City.
"The full extent of the wind, storm surge and rainfall damage in Guerrero will emerge over the coming days," Moody's Risk Management Solutions said in a note.
Mexico's state power utility CFE had more than 1300 employees working to restore power, it said on Wednesday evening, when some 300,000 people remained without electricity.
The main highway connecting Acapulco with Mexico City was expected to be fully open by midday, Deputy Transportation Minister Rogelio Jimenez Pons told reporters on Thursday, noting the impact of mudslides.
The port city's international airport was closed, after Otis wrecked the control tower, cut telecommunications, and left access roads blocked.
"Now a Category 5 hurricane in Acapulco takes us by surprise," Jimenez Pons said.
"It's unprecedented."