Dr Joshua Simmons, a US Army colonel and physician to the vice president, wrote in a letter released on Saturday that Harris, 59, maintains a healthy, active lifestyle and that her most recent physical last April was "unremarkable".
She "possesses the physical and mental resiliency required to successfully execute the duties of the presidency, to include those as chief executive, head of state and commander in chief," he wrote in a two-page letter.
Simmons, who said he has been Harris' primary care physician for the past 3.5 years, said the vice president has a history of allergies and urticaria, also known as hives, for which she has been on allergen immunotherapy for the past three years.
Simmons said Harris' latest blood work and other test results were "unremarkable."
Also in the report: Harris wears contact lenses for mild nearsightedness; her family history includes maternal colon cancer; she is up to date on preventive care recommendations, including having a colonoscopy and annual mammograms.
Republican presidential nominee Donald Trump has released limited details about his health. (AP PHOTO)
Harris' advisers hope to use the moment to draw a contrast with Republican Donald Trump, who has released only limited information about his health over the years, and raise questions about his fitness to serve, according to a campaign aide who spoke on condition of anonymity to discuss sensitive matters.
Trump has released very little health information, including after his ear was grazed by a bullet during an assassination attempt in July.
Trump, 78, eagerly questioned President Joe Biden's health when the 81-year-old president was seeking re-election.
Since Biden was replaced on the ticket with Harris, who is 59, Trump's own health has drawn more attention.