With four months left in office, Biden stepped up to the green-marbled lectern at the UN General Assembly on Tuesday with wars in Ukraine, the Gaza Strip and Sudan still raging and likely to outlast his presidency, which ends in January.
He sought to calm tensions as the nearly year-long war between Israel and Palestinian militants Hamas in the besieged Gaza Strip now threatens to engulf Lebanon - where Israel targeted more than a thousand Hezbollah targets on Monday.
US President Joe Biden addressed the 79th United Nations General Assembly in New York. (AP PHOTO)
"Full scale war is not in anyone's interest, even if situation has escalated, a diplomatic solution is still possible," he told the 193-member UN General Assembly.
To a round of applause, Biden called on Israel and Hamas to finalise the terms of a Gaza ceasefire and hostage release deal put forward by the US, Qatar and Egypt.
Biden's presidency has also been dominated by Russia's February 2022 invasion of Ukraine. Ukrainian President Volodymyr Zelenskiy was in the assembly hall to hear Biden speak and emphasise US support for his country.
"The good news is Putin's war has failed at his core aim. He set out to destroy Ukraine, but Ukraine is still free," said Biden.
"We cannot grow weary, we cannot look away, and we will not let up on our support for Ukraine, not until Ukraine wins with a just, durable peace," he said.
US President Joe Biden sat down with UN Secretary General António Guterres at the summit. (AP PHOTO)
Russia controls just under a fifth of Ukraine, including about 80 per cent of the Donbas area. Russian forces have begun storming the eastern Ukrainian town of Vuhledar, a stronghold that has resisted Russian attack since the beginning of the war, according to Russian war bloggers and state media.
Biden is due to hear from Zelenskiy about a new Ukrainian peace plan when they meet in Washington on Thursday. A US official said the plan is probably much like previous plans calling for more weaponry and support for Ukraine's fight.
Countering China and Iran, which backs both Hamas and Hezbollah, have consumed major chunks of the president's time.
Biden said on Tuesday that progress toward peace in the Middle East would put the world in a stronger position to do "with the ongoing threat posed by Iran."
"Together we must deny oxygen to its terrorist proxies ... and ensure that Iran will never, ever obtain a nuclear weapon," he said.
He said the United States was seeking to responsibly manage competition with China so it does not veer into conflict.
"We recently resumed cooperation with China to stop the flow of deadly synthetic narcotics. I appreciate the collaboration," he said.
Biden also had strong words for the leaders of Sudan's warring parties: "End this war now."
Biden's UN speech is the centrepiece event of a two-day visit to New York that includes a climate speech later on Tuesday and a meeting on Wednesday with To Lam, the president of Vietnam.
While Kamala Harris has decried deaths in Gaza, Donald Trump is a strong supporter of Israel. (AP PHOTO)
Ukraine and Russia, Gaza, Iran and China all figure to linger on as challenges for the next president, whether Biden's successor is his vice president, Kamala Harris, a Democrat, or former President Donald Trump, a Republican.
Harris' approach to foreign policy is much like Biden's, although she has struck a tougher tone on the tens of thousands of Palestinian deaths and the humanitarian crisis in a Gaza Strip devastated by Israeli assaults.
Trump, professing more isolationist tendencies, has little enthusiasm for supporting Ukraine's battle to expel Russian invaders and is a firm backer of Israeli Prime Minister Benjamin Netanyahu, who has frayed relations with Biden.
