Blinken, who has backed Israel while expressing growing concern over civilian casualties, was holding talks on Gaza in the United Arab Emirates and Saudi Arabia on Monday to try to chart a way forward.
He began a five-day Middle East diplomatic effort in Jordan and Qatar on Sunday, his fourth visit to the region since deadly October 7 attacks on Israel by Hamas militants in Gaza sparked a massive Israeli assault that shows no signs of ending.
US Secretary of State Antony Blinken began a week-long trip aimed at calming tensions. (AP PHOTO)
Other Iranian-backed militant groups have weighed in, attacking Israeli forces on the border with Lebanon and US troops in Iraq and Syria as well as ships in the Red Sea, which Blinken said would push up prices of food and fuel.
Israel, which says it is fighting for its very survival, outlined a more focused approach to the war ahead of the visit but Palestinian health officials in the Hamas-run enclave said 247 people had been killed overnight, the highest toll this year.
Israeli forces bombarded the east of the southern city of Khan Younis and central Gaza Strip amid clashes in those areas, residents said. They said a strike in Deir Al-Balah had killed 18 people overnight and four on Monday.
Israel accuses Hamas of operating among civilians and has released videos and photos it says support the claim. Hamas, which is sworn to Israel's destruction, denies the accusation.
The Israeli offensive in Gaza has so far killed 23,084 Palestinians, local health officials say, while Israel says Hamas still holds more than 100 hostages of 240 seized during its October 7 attack on Israeli towns that killed 1200 people.
The military said it had bombed an arms cache and uncovered a tunnel shaft in central Gaza and killed at least 10 fighters in Khan Younis. It dropped leaflets on al Moghani in central Gaza warning residents to evacuate several districts it said were "dangerous combat zones". The military wing of Hamas said a sniper had killed an Israeli soldier in central Gaza.
Nearly all of Gaza's 2.3 million people have fled their homes at least once and many are now moving again, often sheltering in makeshift tents or huddled under tarpaulins.
The UN's Palestinian refugee agency UNRWA reported 63 direct hits on its installations and Ashraf Al-Qidra, the spokesman for the Health Ministry in Gaza, said 1.9 million people in shelters faced famine, drought, and epidemics.
Trucks carrying humanitarian aid to Gaza are inspected at the Kerem Shalom border crossing. (AP PHOTO)
In a sign of international concern, European Union's top diplomat Josep Borrell joined Blinken in Saudi Arabia.
Germany's foreign minister Annalena Baerbock visited Israel, urging it to protect Palestinians in the occupied the West Bank where Israeli forces have killed hundreds in a crackdown. Palestinian President Mahmoud Abbas demanded an end to "Israeli aggression" as he met his Egyptian counterpart in Cairo.
"G7 countries are working with the Israeli government to find a rapid way out of the military phase," the Italian Foreign Ministry quoted minister Antonio Tajani as saying as Italy began its one-year presidency of the Group of Seven.
Blinken said he would tell Israeli officials they must do more to prevent civilian casualties in Gaza and allow Palestinian civilians to return home after right-wing members of Israel's ruling coalition called for Gazans to move elsewhere.
Israeli Defence Minister Yoav Gallant told the Wall Street Journal his country was both determined to end Hamas rule of the enclave and deter other Iran-backed adversaries.
Six sources told Reuters Israel was carrying out an unprecedented wave of deadly strikes in Syria against parts of Iran's weapons lifeline to its proxies in the region.
An Israeli strike on south Lebanon killed a senior commander in Hezbollah's elite Radwan force, three security sources told Reuters. Israel said it hoped Blinken would be able to stop daily Hezbollah attacks that had displaced 80,000 Israelis.
