There was no immediate word on casualties, but all takeoffs and landings from Ronald Reagan National Airport were halted as helicopters from law enforcement agencies across the region flew over the scene in search of survivors. Inflatable rescue boats were launched into the Potomac River from a point near the airport along the George Washington Parkway, just north of the airport.
President Donald Trump was briefed, his press secretary said, and Vice President JD Vance encouraged followers on the social media platform X to "say a prayer for everyone involved".
The Federal Aviation Administration said the midair collision occurred around 9pm local time on Wednesday when a regional jet that had departed from Wichita, Kansas, crashed into a military Blackhawk helicopter while on approach to an airport runway.
In audio from the air traffic control tower around the time of the crash, a controller is heard asking the helicopter, "PAT25 do you have the CRJ in sight", in reference to the passenger aircraft.
"Tower did you see that?" another pilot is heard calling seconds after the apparent collision.
The tower immediately began diverting other aircraft from Reagan.
In a post on social media, American Airlines said it was aware of reports that one of its flights was involved in the incident and said it would provide more information once available.
Video from an observation camera at the nearby Kennedy Center shows two sets of lights consistent with aircraft appearing to join in a fireball.
The airport said emergency personnel were responding to "an aircraft incident on the airfield."
The incident recalled the crash of an Air Florida flight that plummeted into the Potomac on January 13, 1982, that killed 78 people. That crash was attributed to bad weather.
No other details were immediately available.
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