No country has a veto power in the 193-member General Assembly, which is due to vote on a draft resolution that mirrors the language of one that was blocked by the US in the 15-member Security Council last week.
General Assembly resolutions are not binding but carry political weight and reflect global views on the war in the Gaza Strip, as health authorities in the Hamas-run Palestinian enclave say the death toll from Israel's offensive had passed 18,000.
The assembly vote comes a day after 12 Security Council envoys visited the Egyptian side of the Rafah border crossing, the only place where limited humanitarian aid and fuel deliveries have crossed into Gaza.
No country has a veto in the 193-member United Nations General Assembly set to vote on a Gaza truce. (AP PHOTO)
The US did not send a representative on the trip.
"With each step, the US looks more isolated from the mainstream of UN opinion," said Richard Gowan, UN director at the International Crisis Group.
The US and Israel oppose a ceasefire because they believe it would only benefit Hamas.
The US instead supports pauses in fighting to protect civilians and allow the release of hostages taken by Palestinian militants in a deadly October 7 attack on Israel.
In October the General Assembly called for "an immediate, durable and sustained humanitarian truce leading to a cessation of hostilities" in a resolution adopted with 121 votes in favour, 14 against - including the US - and 44 abstentions.
The US and Israel oppose a ceasefire because they believe it would only benefit Hamas. (AP PHOTO)
Some diplomats and observers predict the vote on Tuesday will garner greater support.
A two-thirds majority is needed.
"The dynamics are different to those in October. The length and intensity of Israel's operations in Gaza have left many UN members convinced that a ceasefire is essential," Gowan said.
Israel has bombarded Gaza from the air, imposed a siege and launched a ground offensive in retaliation for the October 7 attack by Hamas that Israel says killed 1200 people and resulted in 240 people being taken hostage.
In October, Canada put forward an amendment to reject and condemn the Hamas attacks on October 7 but it failed to get the two-thirds majority needed.
Diplomats said the US plans to put forward a similar amendment on Tuesday.
The draft General Assembly resolution to be voted on on Tuesday also demands the immediate and unconditional release of all hostages and that the warring parties comply with international law, specifically with regard to the protection of civilians.
Most of the 2.3 million people in Gaza have been driven from their homes and the UN has given dire warnings about the humanitarian situation in the coastal enclave, saying that hundreds of thousands of people are starving.