The round four result has the competition newcomer perched atop the ladder with Collingwood in second spot.
Locke, a former Murray Bushranger, booted three majors in the 6.3 (39) to 3.5 (23) win and was judged third best for Port Melbourne.
The skilful forward's performance takes her season tally of goals to nine.
Former NCWL premiership winning captain for Mooroopna Tamara Smith battled hard for the Cats in the loss.
Rochester's Sarah Ingram helped Carlton clinch its second win of the campaign.
The Blues outsmarted North Melbourne and walked away with a narrow two-goal triumph.
Finley product Eloise Ashley-Cooper and her Essendon teammates enjoyed a 10.10 (70) to 0.3 (3) win over Darebin.
● In AFLW, the action is starting to ramp up with one round remaining until the finals series kicks off.
In the penultimate round, Carlton kept its finals hopes alive with a record-breaking victory over Gold Coast.
The Blues recorded the highest AFLW score as they thrashed the Suns 13.9 (87) to 4.3 (27) at Metricon Stadium.
Shepparton product Grace Egan played a helping hand in the historic result which has left Carlton one win out of the top-six.
The tough inside midfielder finished the game with 19 disposals and four tackles.
Elsewhere, Shepparton export Angela Foley had the last laugh over Mansfield product Bonnie Toogood.
Foley's Adelaide outfit blitzed the Western Bulldogs to the tune of 56 points.
Toogood banged home two goals for the Bulldogs and was a top performer in the loss.
Adelaide is well on its way to adding a third AFLW premiership to its trophy cabinet and sits in third spot on the ladder.
Geelong came within a whisker of notching its first win of the year.
Kyabram's Julia Crockett-Grills (17 disposals, seven tackles) and Benalla's Becky Webster (14 disposals) almost wrangled the Cats over the line, but in the end suffered a seven-point loss to GWS.
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