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Police said it is understood a car crashed into a tree on the Euroa-Mansfield Rd about 4pm on Saturday, November 4.
The driver and sole occupant, an 18-year-old Shepparton woman, was airlifted to hospital where she later died.
The exact circumstances surrounding the crash are yet to be determined and investigations are ongoing.
Anyone who witnessed the incident, has dashcam footage or information is urged to contact Crime Stoppers on 1800 333 000 or log on to www.crimestoppers.com.au/