Mr Birrell, who has been formally endorsed by the party, said he was looking forward to the election campaign and welcomed input from across the electorate.
“I am proud of our region, and I love living and working here,” Mr Birrell said.
“There has been a lot of progress here in the past five years, much of it due to investment by the Federal Government.
“I want to be part of ensuring that continues, and the way that happens is with an engaged National Party member in a coalition government.”
For the past six years Mr Birrell has been chief executive of the Committee for Greater Shepparton.
“I am looking forward to engaging with constituents as I travel around the electorate during the campaign,” he said.
“It is my role to listen to your views and ideas, and to make sure that our leaders in Canberra hear what is important to our community.”
The Federal Election will take place on or before May 21.
Nationals state president Neil Pankhurst said as chief executive of the Committee for Greater Shepparton, Mr Birrell had demonstrated a strong track record of delivering for the people of Northern Victoria.
“I can think of no-one better to represent the people of Nicholls in the Federal Parliament,” Mr Pankhurst said.
“Throughout his career, Sam has demonstrated he knows how to get things done to make our region a better place.”
Retiring Federal Member for Nicholls Damian Drum said Mr Birrell “has a deep passion for our region”.
“He understands the issues facing our communities and will work tirelessly as part of the Nationals team to put Nicholls first,” the Nationals MP said.
Nationals state deputy leader Steph Ryan said she was looking forward to working with Mr Birrell to ensure Nicholls received the resources and funding the region deserved.
“It is important that Nicholls has a federal representative that can be part a coalition government that has a track record of delivering for regional communities,” the State Member for Euroa said.