Fencing went up last week around the former Deniliquin Community Centre, near the corner of Junction St, in preparation.
Building owner Tom Carroll said the demolition would take about three weeks to complete.
Mr Carroll also confirmed other buildings he owns in that area, including the building on the Junction St corner that was home to the Yarkuwa Indigeous Knowledge Centre, are also slated to be demolished.
But he said future use of the land is yet to be determined.
“It’s up in the air,” he said.
While still brandishing the sign writing from when it was the Deniliquin Community Centre, the End St building is probably best known as the original home of the Deniliquin RSL Club.
After an appeal launched on Anzac Day in 1918, enough money had been raised by 1921 to allow for land and a building owned by James Taylor to establish the club.
The soldiers’ clubroom were opened and able to serve alcohol by as early as March 1921.
Remodelling was carried out in 1928 and following the end of World War II to cater for a growing number of members, and a major renovation took place in the 1950s to accommodate the introduction of poker machines.
Continued membership growth led to the decision to build an entirely new RSL, which was completed in 1974.
After the Deniliquin RSL Club moved out of the building, it became home to the then newly formed Council for Social Development Central Murray Region. This organisation later evolved to become Intereach.
The building was then used as a youth centre, with regular discos and activities, but has now been dormant for quite some time.