This brings the total number of active cases in the city to 90.
Professor Ben Cowie said a decision about whether to extend or end Greater Shepparton's lockdown would be made overnight and announced on Friday.
"In the next 24 hours we will again review all of the features, not just case number, but the connections of the cases to others," he said.
Professor Cowie said his colleagues would consult local public health unit colleagues - i.e. GV Health - who have the "on-the-ground intelligence".
There were 1638 new cases across Victoria, all locally acquired. Of those, 115 were in regional Victoria, comprising just seven per cent of the state total.
“This means that there are now 707 active cases outside of Melbourne, but on a positive note, the majority of these have been linked to existing cases,” Prof Cowie said.
Eight new cases have been detected in Ballarat, 16 in Geelong, 17 in the Mitchell Shire, four in Mildura, 15 in Latrobe, 11 in Mount Alexander Shire and 11 in Baw Baw.
Two women sadly died with COVID-19 on Wednesday, a woman in her 60s from Wyndham, and a woman in her 70s from Hume.
There were 564 people in Victorian hospitals with COVID-19 on Thursday, including 115 in ICU and 74 on ventilators.
Of those hospitalised, 66 per cent were unvaccinated, 27 per cent were partially vaccinated and just seven per cent were fully vaccinated.
“These numbers continue to show the power of vaccinations in keeping the vast majority of people out of hospital and especially out of ICU most importantly,” Victorian Disability, Ageing and Carers Minister Luke Donnellan said.
According to the latest figures, 84.4 per cent of people over 16 years of age have now received their first dose of a COVID-19 vaccine in Victoria and 55 per cent are fully vaccinated.
Prof Cowie shared compelling data about the vaccination rates among COVID-19-positive people in Victoria.
“From the seven days to Tuesday this week, we have had about 10,000 cases of COVID-19,” he said.
“Of these cases, seven per cent were fully vaccinated, 15 per cent were partially vaccinated and 79 per cent were unvaccinated - no doses of vaccine.
“And this is unfortunate because it is despite the fact that 87 per cent of the cases were eligible for vaccination at the time that they were diagnosed with COVID-19.”
Mr Donnellan announced a $5 million boost to improve vaccination rates among Victorians living with disabilities, which will involve 10 dedicated vaccine clinics in areas of concern opening this month.
As of September 30, more than 71 per cent of Victorian NDIS participants aged 16 and over had received a first vaccine dose, compared to the national average of 67 per cent.
“We are doing slightly better (than the national average) but it is simply not good enough,” Mr Donnellan said.
Victorians with disabilities will be able to attend any state-run vaccine hub without an appointment and receive priority access to a vaccine from October 8.