Mother-of-two Allison Bernard disappeared after a night out at a hotel in far north Queensland in February 2013.
Now, a $500,000 reward has been offered to solve her mysterious disappearance and give her family answers.
"We, the Bernard family, are still devastated by Allison's disappearance," they said in a statement read out at a Queensland Police news conference in Cairns on Wednesday.
"Her absence continues to impact our lives and community, in particular, her children ... and we encourage anyone who has information that may assist investigations to come forward.
"Family members deserve the respect of having the questions that surround her disappearance answered."
The 23-year-old had been at the Exchange Hotel in Coen before disappearing between nearby Archer River, and her hometown Kowanyama.
Queensland Police conducted a large-scale search of the area but no trace of Ms Bernard was found.
An inquest last year heard the last person to see Ms Bernard was quarry caretaker Thomas Byrnes who has denied any involvement in her disappearance
Ms Bernard is described as Indigenous, 155cm tall, with a slim build and brown hair.
Detective Superintendent Sonia Smith believes the local community holds the key to what happened to Ms Bernard and hopes the reward will spur witnesses to come forward.
"We will not give up. Ms Bernard's disappearance has had a devastating impact on this community and together we won't stop until we find answers," Supt Smith said.
"We will never stop searching and we'll never stop this investigation until we're able to find Miss Bernard and deliver those answers for her family."
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