The Bureau of Meteorology has issued a severe weather warning for inland southern areas of the state, including the Channel Country, Maranoa and Warrego districts.
Up to 100mm is expected with isolated rainfall forecast to cause further flash and river flooding.
The bureau has flood warnings in place - meaning flooding has occurred or is expected - for multiple rivers, including Cooper Creek and the Bulloo, Paroo, Thomson, Warrego and Barcoo rivers.
Heavy overnight downpours also triggered flooding at the Mary River near Gympie.
"There is a lot of water still flowing into these inland catchments and this flooding is likely to continue for quite an extended period of time," meteorologist Jonathan How said.
A major flood warning is also current for the Pioneer River near Mackay and flood warnings are in place for the Ross, Bohle and Haughton Rivers near Townsville.
For inland hotel owner Koss Siwers, his outback business re-opening date is likely to be pushed back after he saw pictures of Queensland's inundated southwest.
Mr Siwers would usually have already completed the 10-hour drive to Adavale from his other residence in Brisbane to reopen the remote hotel, which he runs from March to October.
However, ex-tropical cyclone Alfred's arrival in southeast Queensland in March ensured a dramatic change of plan.
Weeks later, Mr Siwers was again ready to hit the road - until he saw pictures sent online by his Adavale neighbours.
Floodwaters were up to the hotel's floorboards - and rising.
"Here I was in Brisbane and then this bloody cyclone came, so I thought 'geez I better stay' because I was a bit concerned about the property and the neighbours," Mr Siwers told AAP.
"I was just about ready to go on Saturday, now this flooding has happened in a flash - it's bloody unbelievable."
The pictures of an inundated Adavale were sent to Mr Siwers before the outback town's entire population of about 30 was evacuated.
Downpours of up to 400mm have hit the state's central and southwest, triggering widespread flooding.
The wet weather has cut roads, isolated communities and disrupted telecommunications across inland Queensland.
About 500mm had been recorded within a week at Adavale's neighbour Quilpie, representing a year's worth of rain.
"I will have to wait for the water to go down. Usually, it takes about a week," Mr Siwers said of his Adavale Pub plans.
"I was packing up ready to go back with stock, ready to open the pub again.
"Now it looks like all the wet has moved out west."
Premier David Crisafulli said the government's attention will turn to affected primary producers when the flooding and rain subsides.
"There'll be significant livestock loss," he told ABC TV on Friday.
"You're dealing with hundreds of thousands of acres that is underwater and significant loss which has a big economic flows through the communities."
Heavy rain is set to move southeast in the coming days, bringing downpours and possible flooding as far south as northern and eastern NSW.
Weeks after Alfred battered the southeast, sandbagging sites are reopening around Brisbane and the Gold Coast.
The wet weather is set to move south into northern inland and central NSW before tracking east by Saturday.
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