The three-year-old went missing while playing at his foster grandmother's home in Kendall, on the NSW mid-north coast, on September 12, 2014.
The inquest into William's disappearance began in March 2019 but was adjourned in October 2020.
The inquest before Deputy State Coroner Harriet Grahame is due to resume on Monday and run through to Friday, before another week of hearings in December.
A month-long search in 2021 for William Tyrrell's remains ended without any obvious breakthroughs. (Mick Tsikas/AAP PHOTOS)
No one has been charged in the case and a $1 million reward for information still stands.
Despite a decade-long investigation involving hundreds of persons of interest and dozens of searches, no trace of the boy - last seen wearing a Spider-Man suit - has been found.
In November, 2021 police launched a fresh, month-long search for William's remains that concluded without any obvious breakthroughs.
In May, a review into evidence that the three-year-old's former foster mother might have been involved in his disappearance was suspended after a police request to the NSW Director of Public Prosecutions.
Investigators had provided a brief for prosecutors to consider potential charges against the woman, who cannot be named for legal reasons, who they believed might have disposed of William's body after an accidental death.
The foster mother has always denied having anything to do with William's disappearance.
At a directions hearing in August, counsel assisting Gerard Craddock SC told the NSW Coroners Court a list of witnesses and issues still to be addressed was being finalised.