Rose Howell was last seen walking towards her home at Bundagen, south of Coffs Harbour on the NSW mid-north coast, in April 2003.
The 18-year-old's mother reported her missing when she did not show up for an appointment.
Homicide Squad detectives have conducted a number of forensic searches as part of a re-appeal for information into the suspicious disappearance of Rose Howell from the state's north over 20 years ago.— NSW Police Force (@nswpolice) More info: https://t.co/ObtAJBx6eu pic.twitter.com/O035rBK71YAugust 5, 2024
A 2012 coronial inquest found Ms Howell likely died at an unknown time and place, and the case was referred back to the NSW Police unsolved homicide team.
Detectives took another look at the case in 2023, bolstered by a $750,000 reward for information about the teen's disappearance announced in July that year.
"Somebody, somewhere has got some idea of what would have happened to her and we'd really like to know," Ms Howell's mother Malila Howell said at the time.
Police searched around a house using dogs and ground-penetrating radar at Repton, near Bundagen, in June.
A Ford Falcon believed to be linked to Ms Howell's disappearance was forensically examined in July.
Forensic officers inspect Coffs Harbour home looking for clues about Rose Howell's disappearance. (HANDOUT/NSW POLICE)
Homicide Squad commander Danny Doherty said police believed there were people with information that could hold the key to solving Ms Howell's disappearance.
"Her family deserve answers having dealt with the uncertainty of what happened over two decades ago," Detective Superintendent Doherty said on Tuesday.
"The public are reminded that there is no piece of information too small for investigators; your tip could be the missing piece of the puzzle in this investigation," he said.