Isabella Allen from the Australian Securities and Investments Commission said Adam Grimley asked her the loaded question in June 2021.
"How do you feel being responsible for Melissa's death," Mr Grimley told Ms Allen, she said on Monday in the NSW Coroner's Court.
"Do you feel responsible for her death?" her lawyer John Sutton asked.
"No I was doing my job," Ms Allen said.
She also denied the accusation that ASIC officers were "parading" around the expensive luxury items they were seizing from Ms Caddick on November 11, 2020.
Nor did she see anyone putting on Ms Caddick's clothing or hanging jewellery around their neck, "giggling and laughing".
The last verified sighting of Ms Caddick was filmed when ASIC and the Australian Federal Police raided her mansion that day.
Ms Caddick's husband Anthony Koletti has since made several complaints to police about Ms Allen's behaviour during the raid.
And Ms Caddick's mother Barbara Grimley holds ASIC responsible for her daughter's suspected death, saying she was highly distressed during the raid and was not allowed any food or water.
Ms Allen described "as fantasy" the suggestion she was to blame for the current situation.
The AFP's Constable Amelia Griffen shadowed Ms Caddick for the majority of the 12-hour search and confirmed she made herself a protein smoothie in the morning.
"I recall having a conversation with her that she was free to roam around the premises if she wished to do so, Const Griffen said.
Ms Allen also confirmed during the raid Ms Caddick was observed filing her nails "from time to time," and taking a nap in the afternoon.
She did not appear anxious at all and only showed emotion, a "look of horror," when her wedding rings "clanged" as they were put into a ziplock bag, she said.
Ms Allen led the formal investigation into the conwoman's Ponzi scheme operated under her fake company Maliver, from September 8, 2020.
About August 2020 one of her investors, Dominique Ogilvie, had a chance encounter with Jennifer Porter, whose Australian Financial Services Licence Ms Caddick was illegally using as her own.
ASIC conducted a telephone interview with Ms Ogilvie about the investigation on September 14.
"We said if (Ms Ogilvie) were to run into Ms Caddick or have subsequent phone calls or speak to her, she could speak to her freely but keep the contents of our conversation confidential," Ms Allen said.
Data obtained from Ms Caddick's mobile phone indicated her searching for shredding services that evening, and a day later booked the services of Shred-X.
Ms Allen said following the extensive search warrant her team looked closely at some of the evidence shredded.
She determined it was not the result of Ms Caddick being "tipped off by anyone".
Meanwhile, her luxurious five-bedroom, four-bathroom eastern suburbs home has come on the market, boasting uninterrupted and expansive views of Sydney Harbour and a "stunning pool", which receivers hope will fetch at least $10 million.
Mr Koletti reported the 49-year-old as missing some 30 hours after he says she walked out of their home for the last time on November 12 about 5.30am to "go for a jog".
In February 2021 Ms Caddick's decomposing foot encased in an Asics shoe washed ashore at Bournda Beach on the NSW south coast, about 400km south of Sydney.
She preyed on mostly friends and family, and stole up to $30 million between 2013 and 2020, counsel assisting Jason Downing SC earlier told the court.
The inquest before Deputy State Coroner Elizabeth Ryan continues.
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