The Swans lost star forward Tom Papley (ankle) for potentially the rest of the home-and-away season during Sunday's two-point defeat to the Brisbane Lions.
Veteran defender Dane Rampe (calf) will be out for up to two weeks after being injured at the Gabba.
Forward Will Hayward (ankle) bravely played on against the Lions, kicking two goals, and remains a chance to face the Western Bulldogs at the SCG on Sunday.
Swans coach John Longmire all but admitted Papley was irreplaceable as a small forward who pinch hits in the midfield.
Former captain Luke Parker and star midfielder Isaac Heeney could be options to push deeper inside-50 while Papley recovers.
"It's like any any top-line player, you don't automatically replace them with like for like," Longmire said on Tuesday.
"We have to think through that and come up with a solution to that.
"We just have to adapt.
"Every team goes through some challenges at different times with key personnel missing.
"It'll be our opportunity to make the most of that challenge now so it's just part of football."
Isaac Heeney consoles an injured Tom Papley after the Swans' loss in Brisbane. (Darren England/AAP PHOTOS)
After sitting out the match against the Lions due to soreness, captain Callum Mills should return for the clash with the Bulldogs in what would be just his second appearance of the season.
Winger Justin McInerney (knee) remains sidelined, while midfielder James Rowbottom (cheekbone) is pushing to return after also missing the clash in Brisbane.
"He did a drill (at training last) Thursday, he pulled up really well from that, but we didn't want to push him too hard," Longmire said of Mills.
"It gives him another week's training, which he's been able to do."
Despite losing three of their last four matches, the Swans still remain two games and significant percentage clear on top of the ladder with five matches remaining in the home-and-away season.
Longmire was joined at his Tuesday press conference by 2012 premiership player Sam Reid, who has retired, effectively immediately, following a torturous run with injury.
The injury-plagued tall, who was drafted in 2009, was pushing for a return after not appearing at AFL level since the 2022 grand final.
But an injury setback while playing for the Swans in the VFL at the weekend has forced Reid to call it quits after 181 games.
Thank you Reidy. ❤️ — Sydney Swans (@sydneyswans) July 23, 2024After 15 seasons, 181 games and 183 goals in the red and white, Premiership player Sam Reid has called time on his career, announcing his retirement from football, effective immediately. #Bloods Read more: https://t.co/fqhT4UzcFT pic.twitter.com/5C8BKbjIag
The 32-year-old put together one of his best seasons in 2022, but an injury during the preliminary final meant he was sore going into the decider against Geelong.
Reid's retirement means Parker is the only remaining member of the Swans' 2012 premiership team to still be playing.
Reid said that grand final upset of Hawthorn stands out as the on-field highlight.
"Since arriving from Victoria all those years ago I've grown up from a 17-year-old school kid to now having a wife and two kids of my own," Reid said.
"The club has looked after me and my family so well and I can't thank them enough for the opportunity I've been given.
"I will look back with so many great memories of playing here - the people I've been able to work with have been incredible and a big reason why I lasted 15 years."
Swans coach John Longmire hailed Reid's contribution through adversity, calling him a pleasure to lead.
"He has faced many challenges with injuries over the years, and his commitment and dedication to rehab has always been of a very high standard," Longmire said.
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