Errol Gulden is the latest star AFL player to be hurt in the pre-season, with the Sydney midfielder suffering an ankle injury early in the Swans' match against Gold Coast.
The dual All Australian was tackled by Will Graham at People First Stadium on Friday night and his ankle twisted awkwardly under him.
Gulden was in agony as trainers helped him from the ground.
Already on Friday, Port Adelaide confirmed Zak Butters is out for at least six weeks after knee surgery and Western Bulldogs captain Marcus Bontempelli will have a similar spell because of his calf muscle injury.
Suns key position player Mac Andrew also came off second-best in a marking contest at the start of the game and was forced out after barely a minute. He is suspected to have a rib injury.
Swans captain Callum Mills (foot) will miss their opening round home match next Friday against Hawthorn, while ruckman Brodie Grundy is in doubt with a knee injury.
Several Sydney stars were rested for the Gold Coast game, including Isaac Heeney, Chad Warner and Dane Rampe.
The Swans made a fast start, kicking the first four goals and leading by 10 points at quarter time.