Briggs was seen training apart from teammates on Thursday ahead of Saturday's match at the Gabba, with coach Adam Kingsley confirming the ruckman was struggling.
"'Briggsy' is managing some shoulder stuff so he's probably unlikely this week at this point in time," Kingsley said.
"He'll reassess tomorrow but he was a bit sore during the game and certainly post-game.
"Six-day break, travel just makes it a little difficult so I don't expect him to get up."
Kingsley expects Briggs would be missing for just one game.
Kieren Briggs is grounded during the Giants' dramatic last-out win over Hawthorn. (Lukas Coch/AAP PHOTOS)
Key forward and backup ruckman Lachlan Keeffe will most likely slot in for Briggs, with Braydon Preuss out for the season with a back injury.
It will be Keeffe's first AFL match this season should he be selected, after playing 14 games last year.
The 34-year-old will do battle with Brisbane's Oscar McInerney, who is fifth in the league for hitouts (617) after his 36 in their 85-point win against St Kilda last round.
"We've had a few injuries with our ruck stocks so it feels like Keeffe is the next man in and he's more than capable," Kingsley said.
"He played in the ruck last week at VFL level and did quite well so he's one of these guys that adapts pretty quickly.
"We're pretty comfortable that he can mix it with a really good ruckman up there in McInerney.
"There'll be times where Lachie has good moments. There'll be times where McInerney has good moments.
"That's the nature of good players going at it."
Stephen Coniglio is also a chance of returning after the Giants opted to give the vice-captain an extra week to recover from a shoulder injury.
"We did match play and he seemed OK," Kingsley said.
"I haven't actually got the report post that, so we'll just sort of see how that unfolds.
"I can't be definitive about him."
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