Captain of the Eagles' 2018 premiership, the 35-year-old will seek to bow out in the club's final game of the season against Adelaide at Optus Stadium in round 24.
Hurn told teammates of his decision on Tuesday, with West Coast coming off breaking their club-record losing streak with a win against North Melbourne on Sunday.
The hardnosed defender is the only player in West Coast's 35-year history to play more than 300 games.
"I love playing the game and I know I'm really going to miss it," Hurn, who has played 332 games, said.
"But I also know the time is right. People have told me that I would know when this moment arrived and it's here.
"Unfortunately, you can't go on forever and it's time for me to step away.
"I feel very lucky to have played for as long as I have, always wanting to contribute to the team, but ultimately the game does catch up with you - especially at 35."
Hurn was All-Australian in the Eagles' 2018 premiership campaign, and backed it up with a second blazer in 2019 when he was named vice-captain of the team.
His retirement starts what is expected to be an off-season of change at West Coast as they seem destined to collect just the second wooden spoon in club history.
Eagles coach Adam Simpson, who played 306 games for North Melbourne, believed Hurn was one of the best leaders he had seen in the AFL.
"The first thing you want from your leaders is to play well, and there weren't many times in his career when 'Bunga' (Hurn) didn't do that," Simpson said.
"He is one of only three premiership captains in the history of the club and that honour is not gifted to anyone.
"He is just such an honest and humble person and it has been a privilege to have been involved in the second half of his career."
Hurn's announcement comes after Sydney legend Lance Franklin confirmed his retirement from the AFL, effective immediately.
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