The Eagles' current nine-match losing run is the equal worst in the club's 37-year history.
Damningly, West Coast have posted three nine-match losing runs over the past two years - highlighting the injury curse the club has endured over that period.
The Eagles must beat ladder leaders Collingwood in Perth on Saturday night in order to avoid recording a 10th straight defeat.
But with stars such as Luke Shuey, Jeremy McGovern, Nic Naitanui, Jamie Cripps, Liam Ryan Jack Darling and Tom Cole still among a 13-man injury list, West Coast will start as rank underdogs.
"I don't like losing. It's not a great feeling," Simpson told reporters on Friday.
"But it is what it is. As much as I say we can't control it (whether we set a new losing record), of course we can. We can control it by winning.
"But the circumstances of which we've been working under has been quite challenging. The history books won't care."
Despite all the odds being stacked against his side, Simpson isn't giving up hope of guiding the Eagles to a brave victory.
"I go into every game thinking - and I'm sure our players do - that we're a chance here, and that's how I feel this week," Simpson said.
"Effort is a non negotiable, be as competitive as we can, and you never know. What will be will be."
Collingwood (10-1) will be aiming to post their eighth consecutive victory, and they've handed a debut to 19-year-old forward Harvey Harrison.
Billy Frampton returns from a groin injury, but Steele Sidebottom (knee) and Jamie Elliott (shoulder) have been ruled out.
For West Coast, Shuey is set to return for next week's clash with Adelaide, while Darling and McGovern could be ready to go straight after the bye.
Cripps, Cole and Ryan are on track to return in six to eight weeks, but Naitanui's timeline is more uncertain.
Naitanui has been sidelined for the entire season due to an Achilles tendon issue, and he has been listed as being 6-7 weeks away on the club's injury list for the past three weeks.
"It's been slow going. We haven't gotten over the hurdle that you have to get over to get to the next phase," Simpson said.
"I suppose you can call that a setback. It's just not getting to the next level.
"That's why it's hard to give you a timeline.
"Until he gets over this piece, we can't move forward."
Naitanui has played just 67 games since 2016, with that horror run including two knee reconstructions.
