Former Geelong and Port Adelaide forward Francis Evans is the only casualty from last Thursday night, making way for the return of superstar forward Charlie Curnow.
After missing the end of last season due to an ankle injury, Curnow's start to 2025 was hampered by knee issues.
But the dual Coleman medallist is raring to go for this Thursday night's showdown with red-hot Hawthorn, who have surged into premiership favouritism on the back of last year's run to the semi-final and an impressive first two games of 2025.
The Blues were left bitterly disappointed by blowing a 41-point lead against Richmond, who are tipped to claim back-to-back wooden spoons.
But coach Michael Voss is keeping things in perspective that it is only one game into a 24-round season.
Carlton were on the complete opposite end of the spectrum 12 months ago when they stunned eventual premiers Brisbane at the Gabba, coming back from 46 points down to win in Opening Round.
"We don't separate, we don't blame," Voss said of the reaction to losing against the Tigers.
"We're really confident in the body of work over the course of the pre-season.
"I couldn't be more impressed with our prep: it seemed a bit unusual to me what turned up, that doesn't mean it's not addressed.
"We're trying to find the version where we're consistent no matter the circumstance.
"The information we're getting back is we're not that yet.
"We reinforce the things we want to play like, and sometimes in the instances where things don't work well, you've got to double down on those things - you can't just say 'that didn't work, there were a few errors, let's go in a different direction'. That's not strong leadership.
"That's folding to a noise, if you want to call it that."
Undefeated Hawthorn made two changes, replacing suspended defender Jack Scrimshaw with fellow backman Changkuoth Jiath.
Veteran triple premiership forward Jack Gunston has been recalled for his first game of the season, coming in for Sam Frost.
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