After their drought-breaking grand final win over the Western Bulldogs on September 25, the Demons will return to competitive action in a Thursday night contest on March 3.
The Bulldogs will host Brisbane at Marvel Stadium on March 4, while derbies in South Australia (March 5) and Western Australia (March 6) could add some spice to the pre-season schedule.
The Crows-Power match will be played at Richmond Oval, while the Dockers-Eagles meeting will take place at Fremantle Oval.
March 6 will feature a double-header at Giants Stadium, with GWS to host Collingwood and Sydney to take on North Melbourne.
Gold Coast and Geelong will wrap up the pre-season schedule at Metricon Stadium on March 7, nine days before the Melbourne-Bulldogs home-and-away season opener at the MCG.
As previously announced, the Hawthorn-Richmond pre-season match in north-west Tasmania on March 5 will be a fundraiser for victims of Devonport's Hillcrest Primary School tragedy.
Each club will also play one unofficial practice match before the annual pre-season series runs over five days in March.
The practice matches will be held over the last two weekends of February, with clubs to decide the venue, time, date and the format of each game between themselves.
All clubs will play practice matches in their home states, except for the two SA clubs, who will travel to WA.
"The decision to proceed with this model was made in consultation with clubs as we look to safeguard the health and safety of the competition and the community by minimising travel prior to the (home and away) season," AFL fixtures boss Marcus King said.
"Equally, this arrangement provides clubs with the ability to determine individual requirements to best prepare for the season ahead."
2022 AFL PRE-SEASON MATCHES
Carlton v Melbourne, March 3, Marvel Stadium
Western Bulldogs v Brisbane, March 4, Marvel Stadium
Hawthorn v Richmond, March 5, venue TBC
Adelaide v Port Adelaide, March 5, Richmond Oval
Essendon v St Kilda, March 5, Marvel Stadium
GWS v Collingwood, March 6, Giants Stadium
Sydney v North Melbourne, March 6, Giants Stadium
Fremantle v West Coast, March 6, Fremantle Oval
Gold Coast v Geelong, March 7, Metricon Stadium
PRACTICE MATCHES
To be held over the last two weekends in February
Essendon v Western Bulldogs
North Melbourne v Melbourne
Sydney v GWS
Carlton v St Kilda
Collingwood v Hawthorn
Geelong v Richmond
Brisbane v Gold Coast
West Coast v Adelaide
Fremantle v Port Adelaide
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