Swiatek and the WTA Tour announced her withdrawal on Friday.
"Due to personal matters, I'm forced to withdraw from the China Open in Beijing. I'm very sorry as I had an amazing time playing and winning this tournament last year and was really looking forward to being back there," Swiatek said.
"I'm sorry I won't be a part of it this time."
Swiatek has won four of the previous eight WTA 1000-level events played this year but last competed in New York two weeks ago at the US Open, where she lost to Jessica Pegula in the quarter-finals.Â
Swiatek also withdrew from this week's Korea Open in Seoul, citing fatigue.
Others to withdraw from the China Open are No.9-ranked Maria Sakkari, with a continuing shoulder injury, and Danielle Collins, who has an illness.
US Open champion Aryna Sabalenka will be the top-seeded player in Beijing, a tournament at which she has reached the quarter-finals twice in three career appearances.
US Open runner-up Pegula is expected to be seeded No.2.
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