As much as he tried, de Minaur was unable to disguise his despair after his movement was clearly compromised in a 6-3 7-5 6-2 quarter-final loss to inspired Englishman Jack Draper on Wednesday (Thursday AEST).
Australia's big last hope floundered in a sea of forehand errors but a flare up to the hip injury that had sidelined him since Wimbledon ultimately robbed de Minaur of any realistic chance to reach a maiden grand slam semi-final.
"I just want to say I'm very proud of myself, of what I have achieved, all things considering, doing everything I could to be in this position. Today it wasn't meant to be," he said.
"Jack is never easy to play in the best of times, and the way he can spread the court, being a lefty and really move you around the court, it takes a toll on the body. Accumulation of matches takes a toll as well.
"But he played well. He deserves the win. He moved me around the court, and served great.
"In the few chances that I had, I wasn't able to execute."
Australia's world No.10 had beaten the 25th-ranked Draper in all three previous encounters and said he never considered either quitting or not starting the match.
Britain's Jack Draper returns during his straight-sets defeat of Alex de Minaur in New York. (AP PHOTO)
"It's not part of me, part of my DNA," he said.
"I don't like it, if I'm honest. I'm always going to give my best.
"And, look, it could have been naive of me, but I genuinely thought that there was a chance even in that last game going in.
"I thought that there was a chance that I was going to change the match around and go out there and win it.
"So at every stage in that match, I gave myself a shot, with my attitude, with my mindset, to go out there.
"I had some chances as well, that who knows if I would have taken them, then maybe I would still be on court right now.
"So retiring, that's not part of me. Over my career, you'll very rarely witness that."But, looking bothered by the hip injury, the world No.10 struggled to find top gear at Arthur Ashe Stadium as Draper continued his march through the Open draw.
Even Draper admitted he'd received a little leg-up from de Minaur.
"He was struggling a little bit today with something and that helped me a little bit," Draper saidÂ
Regardless, Draper delivered a masterclass to end Australia's singles interest in the final grand slam of the year.
While de Minaur's horror unforced forehand error count hit 18, the classy Brit dictated from the get-go with powerful groundstrokes, big serving and a succession of sumptuous forehand drop shots.
Alex de Minaur and Jack Draper embrace at the net after the Briton's quarter-final victory. (AP PHOTO)
Draper's reward is a first grand slam semi-final appearance on Friday against either world No.1 and reigning Australian Open champion Jannik Sinner or fifth-seeded 2021 US Open winner Daniil Medvedev.
The free-hitting youngster has yet to drop a set all tournament and has conceded a meagre 36 games in 15 sets on the way to becoming the first British man to reach the last four at Flushing Meadows since former world No.1 Andy Murray won the title in 2012.
The 22-year-old's run is eerily similar to that of another English success story when Emma Raducanu shocked the tennis world by winning the women's crown without conceding a set in 2021 as a qualifier.
Draper winning two more matches and lifting the title would not be quite as surprising, but the emerging star's incredible run thus far looks that of a man on a similar journey to Raducanu.
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