After a disappointing North American swing in March, when he lost early in Miami and fell in the semi-finals at Indian Wells, the 21-year-old Spaniard roared back to form on clay on Sunday, clinching his sixth Masters 1000 crown and 10th major title overall, including four grand slams.
On a grey afternoon on Court Rainier III overlooking the Mediterranean, Alcaraz initially appeared out of sorts as Musetti carried on from where he left off in defeating Alex de Minaur in a nerve-shredding semi-final on Saturday.
Musetti broke twice early and capitalised on 11 unforced errors from Alcaraz's forehand to take the opening set, with the Italian's variety and court craft giving him the edge against a hesitant opponent struggling to find his rhythm.
But momentum shifted in the second set.
Alcaraz began to strike with more authority and cleaned up his ground strokes, breaking twice to bag five consecutive games, completely flipping the script.
Musetti, who had played several long matches earlier in the week, began to fade physically under the Spaniard's relentless pace, poise and power.
The final set was a one-sided affair.
Alcaraz broke in the opening game and raced to a 3-0 lead, at which point Musetti received a medical timeout for treatment on his right thigh.
From there, the Spaniard did not look back, closing out the match with clinical efficiency with Musetti managing just eight points in the final set.
Alcaraz's victory in Monte Carlo allows him to surpass Alexander Zverev, reclaiming the No.2 spot in the ATP rankings and moving to the top of the 2025 ATP Race, ahead of Jannik Sinner.
World No.1 Sinner, meanwhile, was granted permission to return to official training facilities on Sunday after a three-month doping suspension.
Alcaraz will next play in the Barcelona Open against a qualifier, boosted by his strong Monte Carlo performance and looking to defend his Roland Garros title when that tournament begins in late May.
