The Sharks will arrive in Las Vegas later than the other three NRL teams participating in the opening weekend of fixtures to be played at Allegiant Stadium next Sunday (AEDT).
While Penrith, Canberra and the Warriors have all touched down already in Vegas to begin acclimatising, the Sharks won't arrive until Monday following a weekend of training at the University of Southern California in Los Angeles.
It's a similar itinerary to that followed by the Sydney Roosters last year, with Trent Robinson's side basing themselves at UCLA in the lead-up to their win over Brisbane.
Fears of a full week in Sin City affecting player performances were unfounded last year.
Manly were the only side to spend their whole trip there in 2024 and upset South Sydney to kick off a campaign that ended in a return to finals.
Gun recruit Addin Fonua-Blake is among the Sharks players never to have visited the US, much less the bright lights of Vegas.
But McInnes shrugged at suggestions the Sharks could be overawed by Vegas's lurid casinos and bars on their later arrival.
"I couldn't care less about all that," the lock told AAP.
"I really think the boys are excited to put on a good show with the game. Obviously there's going to be some good experiences but sitting in a casino and things like that isn't one of them.
"I don't think the boys are too interested in that anyway."
In their off-time in LA, McInnes said the Sharks will be focusing on "wholesome experiences" - they will attend an ice-hockey game as a group, spend time at Venice Beach and pay a visit to a local fire station after the devastating Palisades fires.
The skipper sees no need to remind his teammates there won't be time for blackjack or mojitos in Vegas ahead of their clash with four-time reigning premiers Penrith.
"It's a once-in-a-lifetime opportunity but at the same time we don't go and do this if we're not playing footy," he said.
"So if you want to mess with the footy, it's not going to be enjoyable."
Factoring in only players who have already made their first-grade debuts, the Sharks have the fifth-oldest squad in the NRL this year, with plenty of experience travelling for work.
"We're all professionals and if you want to be a professional footy player in the Cronulla Sharks then you need to go over there and be in it for business," halfback Nicho Hynes told AAP.
"That's anywhere, Magic Round you see all different things happen, in finals games in different cities. You've just got to go over there and treat it like another game of footy."
