The visitors have lost in-form opener Kurtis Patterson to quad tightness, sustained as he belted a match-winning 78 off 48 balls in a 42-run win over Hobart Hurricanes on Monday night.
Former Test batter Cameron Bancroft has been recalled to open for the Scorchers alongside wicketkeeper Josh Inglis.
Australia's T20 World Cup-winning captain Aaron Finch will return from a knee injury to play his first match of the BBL season for the Renegades.
Finch, the second-highest runscorer in BBL history, has been sidelined since the World Cup final against New Zealand last month.
Renegades fast bowler James Pattinson also returns after missing one match through general soreness.
The Scorchers are looking to keep their unbeaten run alive after a perfect 4-0 start to the season.
Melbourne Renegades: Mackenzie Harvey, Aaron Finch, Nic Maddinson (C), Sam Harper, Jake Fraser-McGurk, Mohammad Nabi, Will Sutherland, James Pattinson, Kane Richardson, Reece Topley, Zahir Khan.
Perth Scorchers: Cameron Bancroft, Josh Inglis, Mitch Marsh, Colin Munro, Ashton Turner (C), Laurie Evans, Ashton Agar, Andrew Tye, Jason Behrendorff, Peter Hatzoglou, Tymal Mills.
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