With 13 Wallabies in their match-night 23, the star-studded Reds resisted a spirited fightback from Moana to record a runaway eight-tries-to-five victory on Friday night.
Having trailed 21-0 after a dozen minutes, the Pasifika pulled to within seven points of the lead midway through the second half before the Reds turned the screws at Suncorp Stadium.
Quickfire tries to locks Angus Blyth and Travis Smith in the space of three minutes turned a precarious six-point buffer into a commanding 42-22 advantage for the home side.
There was no coming back for Moana as the Reds registered a season-opening win even without sidelined ex-Wallabies captain Liam Wright.
Revelling in the wet conditions, the Reds bolted out of the blocks with three tries in the opening 11 minutes through Wright's fill-in, tough-nut No.8 Seru Uru, and prolific wingers Filipo Daugunu and Tim Ryan.
Ryan's strike was the so-called Junkyard Dog's 10th try in 10 appearances for the Reds, surely keeping the 21-year-old in the eye of Wallabies coach Joe Schmidt.
The Pacific Islanders reduced the halftime deficit to eight points courtesy of a try to inspirational captain Ardie Savea and a penalty goal to fullback William Havili.
But moments after being injected into the fray, first-choice Wallabies hooker Matt Faesler came off the bench for the Reds to blow the game open.
Faesler peeled off the back of a driving maul to score in the 43rd minute to swing the momentum back in the Reds' favour.
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