The Strikers won the bat flip and elected to bowl first at Blundstone Arena on Thursday night.
Wade opens the batting after missing three games with back troubles, while Lynn - the competition's second-highest run scorer this season - is sidelined with a hamstring injury.
The Strikers are also without Test wicketkeeper Alex Carey, with Jake Weatherald and Harry Nielsen the two inclusions.
A win is critical to the finals hopes of both sides.
The Hurricanes sit in sixth position, two points outside the top four, and need to win their remaining two matches to have a chance of making the finals.
The Strikers are in virtually the same position, sitting fifth on seven competition points - one behind the Melbourne Stars in fourth.
The Strikers cruised to a five-wicket win over the Hurricanes in Adelaide on Tuesday.
HURRICANES: Ben McDermott, Matthew Wade, Mac Wright, Caleb Jewell, Corey Anderson, Tim David, Nikhil Chaudhary, Chris Jordan, Paddy Dooley, Nathan Ellis (capt), Riley Meredith.
STRIKERS: Matt Short (capt), D'Arcy Short, Jake Weatherald, Adam Hose, Thomas Kelly, Jamie Overton, Harry Nielsen, Henry Thornton, David Payne, Cameron Boyce, Lloyd Pope.
20°C