Tommy Fleetwood is not contesting the European Masters in Crans-sur-Sierre, where compatriot and two-time winner Fitzpatrick is the only player who can overtake him on the World Points list.
Fitzpatrick needs to finish tied seventh with one player or better to overhaul his fellow Englishman, although whoever misses out will surely be handed a wild card by captain Luke Donald.
"I can make sure that I'm on that team with a good result this week and that's what I'll be focused on," the 2022 US Open champion Fitzpatrick said on the eve of the tournament on Wednesday.
"There's no doubt about that. Fortunately, it's a place that I've played well before so it's nice to be here.
"It would be so good. That's always a goal at the start of the year when it's a Ryder Cup year.
"You want to be on that team wherever they're playing and you want to be part of it. Hopefully, I can do that this week."
MacIntyre, who occupies the final automatic qualifying place on the European Points list behind Jon Rahm and Rory McIlroy, can be caught by five players, although only a top-three finish would be enough to displace the left-hander.
Nearest rival Yannik Paul would replace MacIntyre with a win no matter what the Scot does and needs to finish at least tied for third with two others, or better, to have a chance.
Poland's Adrian Meronk needs to finish in a tie for second with just one player or better to have a chance, while France's Victor Perez has to win or finish alone in second.
Only a win would be enough for either Rasmus Hojgaard or Adrian Otaegui to climb above MacIntyre.
Perez came close to qualifying for the team in 2021 but narrowly missed out after four missed cuts in five big events during qualifying, including all four major championships.
"Obviously it's been a dream and it's a goal since the start of the year, so it's definitely a focus, but I think with the experience from two years ago I know a little bit more how to handle it," Perez said.
"I probably cared a little too much (for the last campaign), which I think is normal. I think everybody wants to make it."
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