The 30-year-old on Wednesday had her Super Rugby Women's debut green-lit for the Queensland Reds, the utility set to come off the bench against the NSW Waratahs on Sunday.
Caslick had always intended to feature for the Reds this season, but has super-charged her commitment to the traditional code by withdrawing from the remaining two sevens legs in Hong Kong and Singapore.
She won Olympic gold with the side in 2016, and the 29-year-old has been part of the team since 2013, claiming multiple world series titles and the 2022 World Cup.
The three-time world sevens player of the year remains one of the best in the business and has ambitions to compete at a fourth Olympics in Los Angeles in 2028.
Tim Walsh's regenerated side, based in Sydney, will learn to live without her in the meantime, with England's World Cup in August-September and Australia's 2029 showpiece now firmly on the radar.
Fellow Paris Olympians Kahli Henwood (wing), Teagan Levi (centre) and current Australian sevens captain Bella Nasser (bench) will also feature for the Reds, while Maddison Levi remains out with a finger injury.
"Charlotte is a world-class athlete," coach Andrew Fraser said.
"When you add the speed with which she plays and the intellect she has gathered over more than a decade, it's really exciting."She is eager to make an impression. I think the crowd at Ballymore on Sunday is in for a treat just marvelling at what the sevens girls can do."We were delighted with the contributions of Teagan, Kahli and Bella against the Drua."
The Reds beat Fijian Drua in Lautoka last weekend, while the Waratahs, five-time champions, have endured a tight loss and win against the Drua and Western Force respectively this season.