The Invincibles' men's pace duo of Saqib Mahmood and Mohammad Amir ripped the heart out of Birmingham Phoenix's first-innings effort under the Oval floodlights on Tuesday, reducing them to 4-10 after just 17 balls.
Amir and Mahmood took two wickets apiece before - following on from Amanda-Jade Wellington's fine 3-9 for the Invincibles women's team in the opening fixture - another Aussie leg-spinner in the shape of Adam Zampa replicated her success in the evening match with 3-11.
Jacob Bethell and Benny Howell did their best to repair the damage for Phoenix, but their eventual total of 89 never looked enough.
In reply, Invincibles waltzed to an eight-wicket win, captain Sam Billings adding some late hitting, after Tawanda Muyeye struck a 14-ball 23.
Zampa's three-wicket haul came in only seven balls and the 32-year-old NSW-born spinner said: "It was nice to start that way, especially at home, and it was good for us to continue our success from last year.
"It's a really enjoyable competition, I love playing in The Hundred. You feel like it's a really alien concept but once you're playing in it, it's Twenty20 cricket with a couple of tactical changes, I love it."
Zampa told the BBC he was happy with his form and added he felt it's come from plying his trade at the top level for some time.
"It's a bit of everything. I've got a lot of cricket under my belt now and I feel really confident where I can land the ball and put it, which helps from a tactical point of things," he said.
Earlier, a sparkling 71 from Paige Schofield took the Invincibles to a dominant 45-run victory against Phoenix in the women's clash.
Scholfield found admirable company in England youngster Alice Capsey (51) as they put on 90 for the second wicket .
And when Phoenix lost three early wickets in reply -including the run out of their own Australian star in Ellyse Perry for a duck, their fate looked sealed.
New Zealand captain Sophie Devine and Amy Jones put up resistance for the visitors, but the Invincibles' bowling attack - and in particular Wellington - proved too strong and sealed a 45-run win.