Gale, who wrote and produced all three movies in the iconic time travel trilogy with collaborator Robert Zemeckis, has made it clear there are still no plans for a fourth instalment 35 years after the third movie hit the big screen.
Speaking to reporters backstage at the Saturn Awards, Gale - who received the George Pal Memorial Award - said: "People always say, 'When are you going to do Back to the Future 4 and we say, 'F*** you.' "
The franchise followed the adventures of Marty McFly (Michael J. Fox) and Emmett 'Doc' Brown (Christopher Lloyd) as they travelled through time.
The franchise is still a huge part of Gale's life, with a Broadway musical adaptation of the original 1985 classic set to tour the world, as well as plans for a stage production on Royal Caribbean Cruises.
Last year, director Zemeckis admitted he was constantly being asked by Universal Pictures about making another sequel and recently pitched the idea of a film version of the musical, but the studio was not keen.
"I floated that out to the folks at Universal. They don't get it. So, [there's] nothing I can do," he said.
"The musical is more of a companion to the movies than a remake. It's sort of like another … it's a whole other thing. It's a celebration of the movie basically."
Fox previously said he was at peace with Hollywood potentially rebooting the series without him, but didn't think it was likely.
"I don't think it needs rebooting because are you going to clarify something? You're going to find a better way to tell the story? I doubt it."