The British singer-songwriter, 34, has written to Prime Minister Sir Keir Starmer and government officials, pushing for immediate, long-term funding for UK music education.
His letter was also signed by Love Actually director Richard Curtis, musicians Coldplay, Annie Lennox, Harry Styles, Sir Elton John, Stormzy, Paloma Faith, Robert Plant, Fred Again and Eric Clapton and rappers Dave and Central Cee.
In January, Sheeran launched the Ed Sheeran Foundation - an initiative aimed at providing inclusive, high-quality music education.
"We are writing collectively as artists, civil society and industry, appealing to your personal belief in music and the promise of opportunity for all under Labour," the letter says.
"Learning an instrument and getting up on stage - whether in school or a community club - is now a luxury not every child can afford."
They call for a Stg250 million UK music education package to repair decades of dismantling music", after citing a 2019 report from industry group the BPI (British Phonographic Industry) which found there had been a 21 per cent decrease in music provision across five years in state schools.
"Music in and out of school should be for all, not a few," the letter says.
"We understand that there are many pressures. As artists, civil society and industry, we want to be part of the solution."
The letter says "as an industry, we bring in Stg7.6 billion $A15.6 billion) into the UK economy", and that 2024 "was the first in over 20 years without a UK global top 10 single or album in the charts" as American musicians dominated 2024's International Federation of the Phonographic Industry chart release.
It also pointed out the speeches from Brits Rising star Myles Smith, who signed the letter, and group of the year Ezra Collective at the Brit Awards.
"How many more venues need to close, how many music programs need to be cut before we realise that we can't just celebrate success, we have to protect the foundations that make it?" Smith said.
The letter also pushed for music to be funded similarly to sport education, the training of 1000 music teachers, providing money for grassroots projects, music apprenticeships and diversifying the curriculum.
Born in Yorkshire and raised in Suffolk, Sheeran has had 14 UK number-one singles and eight UK number-one albums after beginning his career in 2004.
He has become known in recent years for his charity work including founding the Ed Sheeran Suffolk Music Foundation and donating to his former school Thomas Mills High School and Sixth Form in Framlingham.