Keidean Coleman, Callum Ah Chee and Dan McStay have been forced into the AFL's health and safety protocols, while Jarrod Berry (hamstring) and Jaxon Prior (quad) were ruled out with injury.
The blows come on top of star duo Dayne Zorko and Daniel Rich suffering minor hamstring injuries in last week's 41-point win over the Western Bulldogs.
Mitch Robinson and Ryan Lester have been named for their returns, while Nakia Cockatoo is a chance to play his first AFL match since round five after being named on the extended bench.
Essendon have been bolstered by the return of vice-captain Andrew McGrath (adductor).
Sydney have lost ruckman Tom Hickey to illness for Friday night's clash with the Western Bulldogs, with Peter Ladhams named as his replacement.
The Bulldogs regain ruckman Tim English (concussion) while Mitch Hannan will play his first AFL match since round three after overcoming his own concussion.
Ed Richards (concussion) and last week's unused medical sub Riley Garcia were also named in the 22, with the axe falling on Jordon Sweet, Tim O'Brien, Robbie McComb and Hayden Crozier.
Hawthorn have received an inspirational boost for Sunday's match against Adelaide at Marvel Stadium after captain Ben McEvoy was cleared to return from a fractured neck.
McEvoy suffered the scary injury at training in late March, but he has been included in the side among what will be at least five changes.
Forward Jack Gunston will miss the match after the mid-week death of his father while midfielder James Worpel (shoulder), defender Lachlan Bramble (back), Sam Butler (shin) and Will Day (suspended) go out.
The Crows have lost defender Mitch Hinge (health and safety protocols) and forward Josh Rachele (hip).
Will Hamill, Elliott Himmelberg, Matt Crouch, Ben Davis, Ned McHenry and Shane McAdam have been added to the extended squad.
Collingwood forward Jordan De Goey has been named to take on North Melbourne on Saturday despite suffering tightness in his quad at training on Thursday.
Defender Darcy Moore goes out with a knee injury while Jeremy Howe returns from illness.
North Melbourne have made six changes, headlined by the return of captain Jack Ziebell (facial fracture) and ruckman Callum Coleman-Jones.
Bailey Scott, Aiden Bonar and Flynn Perez were also recalled while last week's medical sub Phoenix Spicer has been named in the 22.
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