Langford (hamstring) and defender Jordan Ridley (concussion) were both hurt during the Bombers' first-up 17.9 (111) to 12.13 (85) loss to Hawthorn at the MCG on Friday night.
Ridley will be unavailable for at least the round-two clash with Adelaide, while Langford's scans on Saturday revealed a right hamstring strain that will sideline him for four to six weeks.
Tall forward Peter Wright (ankle) is also out of action and Scott will look at a range of options to replace Langford, the Bombers' leading goal-kicker of the last two seasons.
"We've got some players that we think are playing pretty well at VFL level, but the options open to us are either personnel based or they're structure based," Scott said.
"We might have to change things, but that's what you have to do in this competition. We'll just adjust."
Ridley was ruled out with concussion after he was caught high by Hawthorn's Jack Scrimshaw, who was also concussed later in the match.
It is another blow for Ridley, who managed just nine games last year and suffered a hamstring strain in pre-season.
The latest setback came as finals hopefuls Essendon dominated a raft of key statistical indicators in their season-opener against Hawthorn but lacked their opponents' class and efficiency.
The Hawks kicked seven of the first eight goals and while the Bombers twice got back within 18 points during the final term, they ultimately fell short.
"They sliced us up through the middle at different stages and we sat back off them a little bit too much, particularly in the first quarter," Scott said.
"I was pleased that we were able to adjust to that and get the game somewhat back on our terms, and I thought in the second half we controlled big parts of it.
"The screen that I look at was flashing green on most metrics, but the one that I don't look at so much is the scoreboard, which wasn't flashing green."
Scott was buoyed by the form of midfielder Jye Caldwell, who had a career-best 36 disposals and 10 clearances, as well as teen forward Isaac Kako's debut.
Kako, a first-round draft pick last year, scored the opening goal of the game with a clever volley under pressure and finished with 1.2 from 14 disposals.
"It was great to see Isaac out there. He did some really good things," Scott said.
"I like the way he pressured and he gives us energy that we haven't had in the forward half in the last couple of years.
"That's only the beginning for Isaac. I think we're going to see him only get better from here."
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