Borthwick has made four changes in personnel and three positional switches for Saturday's clash, including recalling Marcus Smith at full-back and giving Tommy Freeman a first Test start at outside centre.
England's head coach also revealed he sees fly-half Fin Smith as a future option at inside centre, a position that will be filled by flanker Ben Earl if there is an injury to Fraser Dingwall at the Principality Stadium.
Of more immediate concern, however, is ensuring his side fulfil their part of the title-winning equation - securing a try-scoring bonus point and lifting their points difference as high as possible.
France are still strong favourites and would snatch Ireland's crown if they dispatch Scotland in the climax to 'Super Saturday'.
But Borthwick wants England to be in a position to capitalise in the event of an upset in Paris, with the Irish also in the hunt.
"Our aspiration is to win the tournament. That's always been the way we want to go and that's not changed. The team's really clear on what we need to do to put ourselves in that position," Borthwick said.
"Every England supporter would be expecting us to say that's what we aim to do and that's exactly what we aim to do.
"We want to do it by playing fast and by getting the ball to our players with strength and pace and athleticism. That's exactly how we want to play this weekend."
Tom Roebuck's selection on the right wing, Luke Cowan-Dickie's promotion to the front row and Ben Curry's recall at openside completes the new arrivals, with Borthwick performing extensive surgery on his team despite the seven-try rout of Italy.
Ollie Lawrence's ruptured Achilles that will see him undergo surgery next week and is likely to rule him out until next season has forced Borthwick's hand in midfield, but Ollie Sleightholme, Jamie George and Tom Willis have all been axed.
The flux in midfield that began with Henry Slade being dropped against Italy continues with Freeman's move from wing to outside centre being undertaken sooner than initially planned because of Lawrence's injury.
England team: 15 Marcus Smith, 14 Tom Roebuck, 13 Tommy Freeman, 12 Fraser Dingwall, 11 Elliot Daly, 10 Fin Smith, 9 Alex Mitchell; 1 Ellis Genge, 2 Luke Cowan-Dickie, 3 Will Stuart, 4 Maro Itoje (capt), 5 Ollie Chessum, 6 Tom Curry, 7 Ben Curry, 8 Ben Earl.
Replacements: 16 Jamie George, 17 Fin Baxter (Harlequins, 10 caps), 18 Joe Heyes, 19 Chandler Cunningham-South, 20 Henry Pollock, 21 Tom Willis, 22 Jack van Poortvliet, 23 George Ford.
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