In Australia's third-biggest win of all time, Tamika Upton scored five tries and set another up two in a complete domination at Allegiant Stadium on Sunday (AEDT).
Winger Julia Robinson and bench centre Jess Sergis also crossed for hat-tricks for Australia, while Tarryn Aiken was superb at halfback with six assists.
So dominant were the Jillaroos that they ran in 17 tries in the 70-minute fixture to claim their largest victory margin over a tier-one nation.
The win was marred by a horror head-on collision from the first tackle after the break, leaving England prop Vicky Whitfield prone on the ground and Jillaroos front-rower Sarah Togatuki concussed.
Whitfield remained prone on the ground for close to 10 minutes, before being taken off on a stretcher on the back of a medicab.
"She (Whitfield) was out for a very short time. She came around complaining of a headache and a sore neck," said England coach Stuart Barrow.
"She's gone to hospital for a scan...Just waiting for the results on that."
Barrow conceded he would understand if Australia did not want to play England in Las Vegas again next year, admitting his players were shellshocked from the outset.
That is a question the NRL must now ponder.
With no fully-professional women's rugby or NFL competition in America, the NRLW is viewed as a space where rugby league can make an impact.
England conceded tries in four straight sets at different stages in both halves, and scored their only points on the full-time siren through Georgia Roache.
By contrast, Pacific Championship matches between Australia and New Zealand have been far more competitive in recent years, leaving the Kiwi Ferns as a potentially better opponent for the Jillaroos next year.
Women's State of Origin is also viewed as a potential way to sell the game in the US, with last year's three-game series a compelling contest.
Australia's players and coach Jess Skinner insisted the best way to help England was playing more matches, with an end-of-season Ashes already scheduled.
"It would be a great match up if we played the Ferns (in Vegas next year), we are always keen to play them," Skinner said.
"But we are also grateful England came to the party and wanted to play here.
"This is a great platform for them to build the game in their country. And we are about that, women elevating women.
"We are proud of the performance we put up. We play our own game and we came to show on another stage why we are No.1 in the world. And the girls did that."
Upton also showed why she is considered the best player in the world, with a hand in everything for the Jillaroos.
The Brisbane recruit put Jakiya Whitfeld into a gap in the lead up to the Jillaroos' first try before scoring three more herself in the opening half.
Isabelle Kelly was dominant at left centre, scoring twice and laying on a nice try for Upton when she swept out wide and passed back inside for her fullback.
Prop Shannon Mato ran for close to 200 metres, while second-rower Olivia Kernick laid on two tries in her first Jillaroos game since her controversial axing last year.
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