Henry Martín scored a brace while one each from Raúl Jiménez and Jorge Sánchez were enough to see them advance.
With the 4-2 aggregate victory in the quarter-final, Mexico now meet Canada on March 20 at Inglewood, California. Three-time defending champions the United States will face Panama in the first game of the semi-finals doubleheader.
In Toronto, Jonathan David got his record 31st goal for Canada and Jacob Shaffelburg scored twice in a 3-0 win over Suriname for a 4-0 aggregate victory.
With Mexico coming off a 2-0 loss in the first leg on Friday at San Pedro Sula, Jiménez started the comeback in the 42nd minute when he scored from Jesús Orozco's cross for his 35th international goal.
Martín tied the aggregate in the 72nd after Jiménez headed Alexis Vega's corner kick across the goal mouth. Sánchez scored in the 85th, chesting Vega's cross and putting a right-foot shot over goalkeeper Edrick Menjivar from seven yards.
Martín converted a penalty kick in the seventh minute of second-half stoppage time for his 11th international goal after Kervin Arriaga was called for tripping Martín near the top of the penalty area by Canadian referee Drew Fischer.
In Canada, David put the hosts ahead in the 23rd minute after an attempted clearance following a corner kick rebounded to him off Shaffelburg. With his fourth goal in six games, David moved past Cyle Latin as Canada's leading scorer.
Shaffelburg beat goalkeeper Etienne Vaessen to a long ball from Moïse Bombito in the 30th, rounded the keeper and scored into an empty net. He then scored from a Larin cross in the 67th minute for his sixth international goal.
Larin hit a post in the 80th minute, prompting a premature in-stadium fireworks celebration and Larin to fall over in disbelief.
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