Along with the 11 newcomers, there will be lots of faces in general - with 35 entries from the professional ranks to the traditional curtain-raiser.
Australia's Grace Kim, winner of 2023's Lotte Championship, will be among those teeing off at Lake Nona in Orlando, Florida, on Thursday.
The only predictable pillar to lean on as the LPGA begins its 74th season is that golf fans are highly likely to see some unpredictable things.
A year ago, US pair Lilia Vu and Allisen Corpuz, Ruoning Yin of China and Celine Boutier of France all began the year having never won a major.
The 26-year-old Vu now has two to her credit - the Chevron Championship and Women's British Open - and makes her Tournament of Champions debut at Lake Nona.
Who will be next to break through? And which seasoned players - standouts including Nelly Korda and New Zealand's Lydia Ko - will bounce back after 2023 seasons that fell short of expectations?
"It's great (that) you're not sure if the world No.1 Lilia Vu will win, or it might be a name that we are not as familiar with," said Ko, a former global-rankings leader who currently sits 12th.
"That's just the name of the game ... you never know who's going to win.
"We're definitely seeing a bigger variety of players ... that are playing really well."
On top of that list is Vu, last season's LPGA player of the year, who starts the season top of the women's world ranking.
The season-opener features LPGA winners from the last two campaigns playing alongside a field of celebrities from the sports and entertainment sectors.
It's a relaxed way for the LPGA players to start anew, getting in four rounds in a no-cut event at a well-kept venue that played host to the first Solheim Cup in 1990.
Brooke Henderson of Canada won the event a year ago - but didn't win again in 2023.
"This is a great way to start out the year," Henderson said.
"It's an amazing atmosphere. It's really fun. It's just a little bit more chill and great vibes."
The LPGA welcomed 12 first-time winners in 2023, 11 of whom have made the trip to Orlando to play this week.
First-timers include Rose Zhang, 20, who won in her LPGA debut last season at the Mizuho Americas Open.
Another first-time LPGA winner was Mone Inami of Japan, the silver medallist from the Tokyo Olympics.
She wasn't a tour member when she won the Toto Japan Classic in her home country in November and has since taken up membership.
This will be a busy season for the LPGA, which has 33 events on its schedule and will compete for more than $US118 million ($A181 million) in prize money.
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