The prime minister will touch down at Uluru on Tuesday evening where he will meet with representatives from the Central Land Council.
The visit will be part of a nationwide blitz advocating for enshrining an Indigenous voice to parliament and executive government in the constitution ahead of Saturday's referendum.
Mr Albanese told Adelaide radio station 5AA there was nothing to fear from the voice proposal.
"It won't make a difference to the way that we're governed but what it will do is enable us to listen," he said.
"A vote for 'no' is a vote to keep things the same, to say that this is as good as it gets for Indigenous Australians. But surely we can do better."
The visit to Uluru will be more than six years since the call for the Indigenous voice was laid out as part of the Uluru Statement from the Heart.
Meanwhile, the Australian Electoral Commission has expressed concern over "unacceptable conduct" of a small number of voters in the lead up to the voice referendum.
With early voting under way, electoral commissioner Tom Rogers urged greater civility, saying tensions were heightened compared to a federal election.
"That's probably a reflection of the kind of debate that we're seeing in public in any case, which I think during a referendum always tends to be a bit more visceral than at a normal election," he told ABC radio on Tuesday.
"A referendum unleashes passions that can boil over and we've seen what I would call unacceptable conduct, including some filming of our staff who are just trying to do the right thing."
More than 21,800 people have cast votes in remote communities before polling day - exceeding all remote votes cast in last year's federal election.
So far, 2.87 million votes have been cast.
Mr Rogers said he was aware of misinformation being circulated by campaigners about the referendum process, calling it "nonsense".
"Votes are treated with the utmost respect, we treat them like a democratic blank cheque that we cash on behalf of all Australians," he said.
The comments come as research from the University of Melbourne into popular Chinese messaging app WeChat found discussion about the voice on the platform has been dominated by right-wing rhetoric and misinformation.
One particular account called YamiChew published 'no' campaign videos featuring misinformation about the potential for the voice to undermine constitutional integrity and Indigenous privilege.
The videos have received tens of thousands of reposts and hundreds of comments.
Pro-voice content and videos from official political groups were lucky to receive more than 20 likes.
Mr Albanese has accused Opposition Leader Peter Dutton of taking part in the spread of misinformation.
Mr Dutton has continued to claim the voice will divide Australians and waste taxpayer money that could spent on practical solutions.
"(The prime minister) has divided the country," he told Sky News.
"I hope that people do make the effort to get out and vote because this would be the most detrimental change to our constitution in our nation's history.
"We live in the best country in the world - we should be prepared to stand up and defend it to make sure that our institutions are protected."