Gun ruckman Darcy hurt his ankle against Collingwood in round 18 and missed last weekend's clash with Sydney, the club confirming on Monday he will have surgery to repair ligament damage.
Fyfe will have surgery on a pre-existing finger injury, having been ruled out for the year with a stress fracture in his foot.
Fremantle said Fyfe had originally intended to get the finger surgery at the end of the season, but it was brought forward when confirmed he won't feature again this year.
The Dockers were already long odds to play finals but it certainly doesn't help their chances, 10 premiership points and considerable percentage outside the eight.
Elsewhere, Essendon's bid to make finals has also suffered a setback with star defender Jordan Ridley likely to miss the remainder of the home-and-away season.
Bomber Ridley hurt his quad during the last quarter of the Bombers' 41-point defeat to the Western Bulldogs on Friday night.
The Bombers on Monday confirmed the 24-year-old suffered a "high-grade" quad strain.
"It's disappointing for Rids who has been one of our most consistent players this season," Essendon performance manager Dan McPherson said.
"We'll get a more accurate sense of his potential return-to-play timeline in the next week or so, but at this early stage we believe he is unlikely to play before the last round of the home-and-away season."
Essendon slumped to 11th with the loss to the Bulldogs but have winnable games against Sydney, West Coast, North Melbourne and GWS, before a final round showdown with premiership favourites Collingwood.
And Adelaide have been dealt a double injury blow from their loss to Melbourne, with reliable defender Nick Murray and goalsneak Izak Rankine set for stints on the sideline.
Murray is out for the year after rupturing his ACL, while Rankine is expected to miss a month with a hamstring injury.
"Obviously it's shattering news for Nick and the team," Adelaide high performance manager Darren Burgess said after scans on Monday confirmed Murray would need a knee reconstruction.
"He's been in great form and taken significant steps in his development in the past three years.
"Knowing the player he is, he will attack his rehab with the right attitude and be back bigger and better."
The Crows will need to find another livewire up forward to keep their season alive, with Rankine having booted 35 goals this year.
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